MicroRNA‑30a controls the instability of inducible CD4+ Tregs through SOCS1
نویسندگان
چکیده
منابع مشابه
CD4+ Tregs and immune control.
Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25+CD4+ Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance ...
متن کاملIn Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4+CD25− Cells in Mice
BACKGROUND Regulatory T cells (Tregs) were shown to be central in maintaining immunological homeostasis and preventing the development of autoimmune diseases. Several subsets of Tregs have been identified to date; however, the dynamics of the interactions between these subsets, and their implications on their regulatory functions are yet to be elucidated. METHODOLOGY/PRINCIPAL FINDINGS We emp...
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colleagues [1] in a recent issue of Arthritis Research & Th erapy. Th ey hypothesized that co-transduction of CD4 + T cells with both forkhead box P3 transcription factor (FoxP3) and Bcl-xL will gener ate highly reactive regulatory T cells (Tregs) that can be used to prevent auto immune disease. Th e authors showed that the accu mulation, persistence, and effi cient function of Tregs were attri...
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چکیده ندارد.
15 صفحه اولCD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.
We identified CD8(+)CD122(+) regulatory T cells (Tregs) and demonstrated their importance in the maintenance of immune homeostasis and in the recovery from experimental autoimmune encephalomyelitis. In this paper, we show that CD8(+)CD122(+) Tregs effectively prevent and cure colitis in a mouse model. In our experiments, colitis was induced in lymphocyte-deficient RAG-2(-/-) mice by transferrin...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2019
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2019.10666